G protein-activated inward rectifier potassium channel 1 (GIRK-1) is encoded in the human by the gene KCNJ3.
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a hetero-tetrameric pore-forming complex.
Interactions
KCNJ3 has been shown to interact with KCNJ5.
See also
- G protein-coupled inwardly-rectifying potassium channel
- Inward-rectifier potassium ion channel
References
Further reading
External links
- KCNJ3 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
